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T Cell Types and Functions01:24

T Cell Types and Functions

996
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
996
Autoimmune Disorders01:29

Autoimmune Disorders

409
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
409
What is the Immune System?01:38

What is the Immune System?

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Overview
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

697
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
697
Inflammatory Response01:28

Inflammatory Response

1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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相关实验视频

Updated: Jun 21, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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在自身免疫性疾病中的调节性T细胞功能障碍.

Dionne Y Honing1,2, Rosalie M Luiten1,2, Tiago R Matos1,3

  • 1Department of Dermatology, Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

International journal of molecular sciences
|July 13, 2024
PubMed
概括

调节性T细胞 (Tregs) 对于免疫平衡至关重要,但在自身免疫性疾病中被破坏. 了解Treg多样性和鉴定对于开发有效的Treg疗法至关重要.

关键词:
自身免疫性疾病是一种自身免疫性疾病.免疫学 免疫学 免疫学监管性T细胞监管性T细胞

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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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相关实验视频

Last Updated: Jun 21, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.7K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

9.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 调节性T细胞 (Tregs) 对于维持免疫平衡和周围耐受性至关重要.
  • 调节 Treg 功能或数量的失调与各种自身免疫性疾病的发病有关.
  • 向Tregs是一个有前途的治疗策略,用于自身免疫性疾病.

研究的目的:

  • 审查Tregs的抑制机制,亚种群,分类和识别方法.
  • 阐明Tregs在自身免疫性疾病的发病过程中的作用.
  • 解决阻碍Treg调节疗法的发展的复杂问题.

主要方法:

  • 对Treg抑制机制的文献综述.
  • 对Treg亚群和分类系统的分析.
  • 对Treg识别方法的检查.
  • 对Treg参与自身免疫性疾病病原发生的审查.

主要成果:

  • Tregs使用各种抑制机制来维持免疫平衡.
  • 在Treg亚群中存在显著的异质性,这使得它们的研究变得复杂.
  • 目前的Treg识别方法各不相同,导致治疗开发的复杂性.
  • 被破坏的Tregs在自身免疫性疾病的发展和进展中发挥着关键作用.

结论:

  • 对Treg生物学的全面理解对于推进自身免疫性疾病治疗至关重要.
  • 标准化Treg的识别和分类可以促进治疗的发展.
  • 针对特定Treg群体的向调制具有治疗自身免疫性疾病的潜力.