反应性氧物种 (ROS) 介导的抗菌氧化疗法:生成ROS的可用方法和新选项提案
Silvana Alfei1, Gian Carlo Schito2, Anna Maria Schito2
1Department of Pharmacy (DIFAR), University of Genoa, Viale Cembrano, 4, 16148 Genoa, Italy.
International journal of molecular sciences
|July 13, 2024
概括
耐多药性病原体是一个全球性威胁. 来自生物炭的持久性自由基提供了一种新的抗菌策略,通过产生用于氧化疗法的活性氧物种 (ROS).
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 环境科学 环境科学
背景情况:
- 多药耐药 (MDR) 病原体构成了全球健康的重大挑战,需要新的抗微生物策略.
- 反应性氧物种 (ROS) 越来越多地被探索用于治疗MDR感染,有前景的局部应用已经获得批准.
- 生物炭 (BC) 是一种碳状物质,具有持久性自由基 (PFR),能够通过先进的氧化过程 (AOP) 产生ROS.
研究的目的:
- 审查ROS在抗微生物治疗中的作用.
- 讨论目前诱导ROS产生用于抗菌目的的方法.
- 建议生物炭衍生的PFR作为抗微生物氧化疗法中ROS生成的新型来源.
主要方法:
- 关于ROS生产,调节和抗菌机制的文献综述.
- 讨论现有用于治疗应用的ROS诱导方法.
- 探索生物炭的特性和通过PFR介导的ROS生成.
主要成果:
- 在生理和病理过程中,ROS具有双重作用,具有潜在的抗菌作用.
- 存在各种方法来诱导用于治疗的ROS,尽管临床验证正在进行中.
- 生物炭的PFR已经证明了对常见的病原体如大肠杆菌和金黄色杆菌的抗菌活性.
结论:
- 来自生物炭的PFR代表了产生ROS的新有前途的来源.
- 这种方法为通过AOPs的抗微生物氧化疗法提供了一个新的途径.
- 对BC-PFRs的进一步研究可能会导致对挑战MDR感染的新疗法.
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