动脉样硬化心血管疾病的炎症和免疫机制在艾滋病毒
Laura Hmiel1, Suyu Zhang2, Laventa M Obare3
1Department of Medicine, Division of Infectious Disease, MetroHealth Medical Center and Case Western Reserve University, Cleveland, OH 44109, USA.
International journal of molecular sciences
|July 13, 2024
概括
艾滋病毒感染者 (PLWH) 面临较高的动脉样硬化风险,原因是免疫失调和炎症. 本综述探讨了这些途径和潜在的治疗方法,以降低PLWH中的心血管风险.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
背景情况:
- 动脉样性血管疾病 (AVD) 在感染艾滋病毒 (PLWH) 的人群中更为普遍.
- 艾滋病毒感染,并发症和并发症导致PLWH患者心血管风险增加.
- 了解PLWH中AVD的免疫和炎症基础至关重要.
研究的目的:
- 审查目前关于免疫和炎症途径驱动动动脉硬化在PLWH的知识.
- 确定导致该人口心血管风险过高的关键因素.
- 突出潜在的治疗目标,以减轻PLWH的AVD.
主要方法:
- 关于艾滋病毒,炎症和动脉样硬化研究的文献综述.
- 在PLWH中分析免疫和炎症机制.
- 病毒,细胞和分子介质的识别.
主要成果:
- 与艾滋病毒相关的免疫失调和慢性炎症显著加速动脉样硬化.
- 病毒产物,可溶性介质,化学因子和免疫细胞起着至关重要的作用.
- 同时感染会加剧炎症负担和心血管风险.
结论:
- 针对特定的免疫和炎症途径提供了一个有前途的策略,以减少PLWH中心血管风险.
- 需要进一步的研究来开发和验证艾滋病毒感染人口中AVD的新疗法.
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