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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
556
Pleiotropy01:33

Pleiotropy

40.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Incomplete Dominance01:43

Incomplete Dominance

22.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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相关实验视频

Updated: Jun 21, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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在牛皮的功能基因组学.

Stefano Rossi1, Ellie Louise Richards1, Gisela Orozco1

  • 1Centre for Genetics and Genomics versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

International journal of molecular sciences
|July 13, 2024
PubMed
概括
此摘要是机器生成的。

牛皮是一种自身免疫性皮肤疾病,影响生活质量. 本综述探讨了遗传风险因素如何影响基因表达,帮助精准医学治疗牛皮.

关键词:
在GWAS中,GWAS就是GWAS.功能性基因组学 功能性基因组学这是一种炎症炎症炎症炎症.精准医学是一门精准医学.牛皮是一种牛皮.

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科学领域:

  • 皮肤病学 皮肤病学
  • 遗传学 遗传学 是一个
  • 免疫学 免疫学 免疫学

背景情况:

  • 牛皮是一种普遍存在的自身免疫性皮肤疾病,具有重大的社会和生活质量影响.
  • 全基因组关联研究 (GWAS) 已经确定了许多与牛皮相关的遗传风险位点.
  • 了解这些位点的功能作用对于破译牛皮病原体至关重要.

研究的目的:

  • 审查目前关于牛皮风险位置的功能基因组学的研究结果.
  • 整合分子生物学技术和高通量技术的见解.
  • 突出这些工具在识别牛皮的新疗法点方面的重要性.

主要方法:

  • 审查关于牛皮遗传学和功能基因组学的现有文献.
  • 讨论已建立的分子生物学技术,包括集群定期间隔的短Palindromic重复 (CRISPR).
  • 集成高通量技术用于基因表达分析.

主要成果:

  • 遗传风险位置在牛皮的复杂性中起着重要作用.
  • 功能性基因组学方法对于理解牛皮中的基因表达改变至关重要.
  • 克里斯普尔和高通量技术为研究这些机制提供了强大的手段.

结论:

  • 阐明牛皮风险位的功能是了解疾病机制的关键.
  • 先进的分子工具对于剖析牛皮的基因表达变化至关重要.
  • 这种知识对于开发向治疗和推进皮肤病学精准医学至关重要.