围产期心血管特征与在孕产妇孕前症中的 ангиотензин系统表达的关联
I-Chun Lin1, Kay L H Wu2, Hsin-Hsin Cheng3
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung 833, Taiwan.
International journal of molecular sciences
|July 13, 2024
概括
在子宫中暴露于孕前症会影响新生儿的心脏动脉和血管激素系统. 这些与母亲血压相关的变化表明胎盘对胎儿心血管发育有影响.
科学领域:
- 心血管生理学心血管生理学
- 围产儿医学 围产儿医学
- 内分泌学 在内分泌学.
背景情况:
- 孕前 (PE) 是一种怀孕并发症,具有潜在的长期心血管影响.
- 氨酸-动脉素系统 (RAS) 在心血管调节中起着至关重要的作用.
- 产前PE暴露对新生儿心血管特征和RAS表达的影响尚未完全理解.
研究的目的:
- 研究产前怀孕前暴露对围产期心血管参数的影响.
- 检查暴露于PE的新生儿中血管酶系统组件的变化.
- 探索PE,心血管特征和血管素系统表达之间的关系.
主要方法:
- 对母亲-新生儿二有或没有孕前的前性研究 (n=49PE,n=48对照).
- 评估新生儿冠状动脉大小,带血氨基酶-N和白细胞ANPEP mRNA水平.
- 测量了血管酶II受体 (AT1R,AT4R) 的内皮mRNA水平和动脉AT2R和AT4R的蛋白质表达.
主要成果:
- 新生儿有更大的冠状动脉和更高的带血氨基酶-N,与母亲的透静血压相关.
- 在PE新生儿中,ANPEP mRNA下降,与新生儿静脉血压相关,并减少了内皮血管细胞粘附分子-1.1.
- PE带血增加了内皮AT1R和AT4RmRNA;动脉显示AT2R和AT4R蛋白表达减少. AT1R mRNA确定了母亲的SBP,AT4R mRNA确定了新生儿的心脏参数.
结论:
- 产前孕暴露会影响新生儿的产前心血管发育和血管素系统表达.
- 在PE中因子的交叉胎盘转移可能会调解这些心血管和内分泌变化.
- 需要进一步的研究来阐明这些观察到的相关性背后的机制.
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