替代传统局部剂量形式的替代方案,用于针对性地透皮肤的迪克洛菲纳克
Benjamin Gavinet1, Séverine Sigurani1, Christine Garcia1
1Research & Innovation, Seppic, 127 Chemin de la Poudrerie, 81100 Castres, France.
International journal of molecular sciences
|July 13, 2024
概括
评估了新的局部药物输送系统,奶油凝和油中的凝乳液,对狄克洛芬雅克的皮肤透. 这些配方为控制药物吸收和提高局部治疗疗效提供了有希望的方法.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 有效的局部药物递送依赖于控制活性药物成分 (API) 穿透皮肤.
- 剂型选择对于优化局部药物的有效性和安全性至关重要.
- 新兴的配方,如奶油凝和油中的凝乳液,为API交付提供了新的途径.
研究的目的:
- 为了评估diclofenac的奶油凝和油中的凝乳液配方的皮肤透能力.
- 为了将这些新型配方与迪克洛芬雅克输送的乳液基准进行比较.
- 调查透增强剂对狄克洛芬雅克皮肤透和保留的影响.
主要方法:
- 使用人体皮肤进行体外皮肤透测试.
- 用不同的溶剂和软化剂度制备奶油凝和油中的凝原型.
- 开发的配方的风病学特征.
- 评估二二甲在受体液中的扩散和皮肤保留.
主要成果:
- 奶油凝配方显示,与乳化凝基准相比,迪克洛菲纳克的皮肤透率更高.
- 油中的凝乳液呈现出二二烯在受体液中扩散的减少,这表明系统暴露的可能性有限.
- 透增强剂 (乙烯糖醇,乙烯糖醇单乙烯) 根据它们在分散或连续阶段和配方类型的结合,以不同的方式调节了二二烯的透.
- 风湿学特性表明适合局部应用,凝在油乳液显示了有利于按摩的特征.
结论:
- 奶油凝和油中的凝乳液是可行的多功能剂型,可调节迪克洛芬雅克透到皮肤.
- 这些配方为优化局部药物输送提供了明显的优势,平衡皮肤保留与最小化全身吸收.
- 这项研究扩大了制定科学家的选择,旨在提高局部药物性能.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336
01:16Drug Delivery: Overview
285
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
285
01:22Routes of Drug Administration: Overview
6.1K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.1K
01:23Local Anesthetics: Common Agents and Their Applications
431
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
431
01:15Non-Oral Extravascular Drug Absorption Routes
209
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
209
01:25Routes of Drug Administration: Parenteral
1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K