肠道和皮肤微生物组及其与老龄化时钟的关联
Mildred Min1,2, Caitlin Egli1,3, Raja K Sivamani1,2,4,5,6
1Integrative Skin Science and Research, 1451 River Park Drive, Suite 222, Sacramento, CA 95819, USA.
International journal of molecular sciences
|July 13, 2024
概括
肠道和皮肤的微生物组可以使用老化时钟来预测生物年龄. 这些基于微生物的衰老时钟为衰老提供了潜在的治疗策略.
科学领域:
- 微生物学 微生物学
- 地质科学是地球科学.
- 生物技术是生物技术.
背景情况:
- 老化时钟使用各种生物标志物来模拟生物年龄,包括表观遗传变化和血液标志物.
- 新兴研究表明,人类微生物群,特别是肠道和皮肤微生物群,可能是衰老的预测因素.
- 微生物组的作用超越了免疫和屏障功能,影响全身衰老过程.
研究的目的:
- 审查肠道和皮肤微生物对老化时钟的影响.
- 为了区分时间和生物年龄.
- 探索基于微生物的衰老时钟在治疗应用中的潜力.
主要方法:
- 对现有文献进行了叙事审查.
- 在PubMed/MEDLINE数据库中进行文献搜索.
- 关键词包括:"皮肤微生物组"或"肠道微生物组"和"衰老钟"或"表观遗传学".
主要成果:
- 可以利用肠道和皮肤微生物组来开发基于分类学组成,生物多样性和功能配置文件的衰老时钟.
- 特定的微生物群落和代谢途径对衰老时钟的准确性和生物年龄预测有显著的贡献.
- 微生物群通过调节时钟基因直接影响衰老的时钟,并通过代谢物生产间接影响.
结论:
- 基于微生物组的衰老钟显示出预测生物年龄的前景,并可能提供治疗途径.
- 进一步的研究是必不可少的,以充分阐明微生物群和衰老过程之间的复杂相互作用.
- 了解这些相互作用可能会导致针对与年龄相关的疾病进行新的干预措施.
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