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Venkat R Pannala1,2, Michele R Balik-Meisner3, Deepak Mav3

  • 1Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, Frederick, MD 21702, USA.

International journal of molecular sciences
|July 13, 2024
PubMed
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这项研究研究了[特定因素]对[特定结果]的影响. 结果表明存在显著的相关性,这表明[关键摘要].

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...