可穿戴式酒精监测设备用于数据驱动的通过皮肤的酒精扩散模型
Ahmed Hasnain Jalal1, Sepehr Arbabi2, Mohammad A Ahad3
1Department of Electrical and Computer Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Sensors (Basel, Switzerland)
|July 13, 2024
概括
这项研究开发了一种可穿戴设备和模型,用于非侵入性血中酒精含量 (BAC) 监测. 指数线性模型准确地预测了通过皮肤的酒精扩散,提高了实时BAC测量的可靠性.
科学领域:
- 生物医学工程 生物医学工程
- 化学工程是化学工程的重要组成部分.
- 身体生理学 身体生理学
背景情况:
- 可穿戴式酒精监测需要准确的,实时的,非侵入性的血中酒精含量 (BAC) 测量.
- 由于皮肤的复杂性和生理因素,目前的穿皮装置缺乏可靠性.
- 需要一个强大的扩散模型来提高通过皮肤监测酒精的准确性.
研究的目的:
- 开发一种使用人类手腕实时数据的穿皮酒精扩散模型.
- 了解皮肤表皮层内的酒精动力学,以改善BAC监测.
- 为未来的大规模研究建立一个计算模型.
主要方法:
- 制造了一个可穿戴的BAC监控设备,配有PEMFC传感器,电位器和BLE收发器.
- 从8名志愿者的手腕收集实时通过皮肤进行酒精扩散的数据.
- 通过比较实验数据与断片线性,指数线性和Hoerl函数来开发和优化一个扩散模型.
主要成果:
- 指数线性函数提供了最适合实验性透皮酒精扩散数据.
- 皮肤表皮层厚度减少20%被证明会导致更快的酒精扩散动态.
- 该模型显示,大约需要60分钟才能达到角层中最大的酒精度.
结论:
- 开发的透皮酒精扩散模型增强了对皮肤中酒精动态的理解.
- 该模型作为更准确的可穿戴,非侵入性的BAC监控设备的基础.
- 该研究强调了皮肤特性和消耗水平对BAC测量准确性的影响.
相关概念视频
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Physical Properties of Alcohols and Phenols
Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Protection of Alcohols
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Mass Spectrometry: Alcohol Fragmentation
Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the intensity of the molecular ion peak in the mass spectrum is weak or sometimes absent. The fragmentation patterns for alcohols occur in two ways, i.e. ⍺-cleavage and dehydration. During ⍺-cleavage, the bond at the ⍺-position adjacent to the hydroxyl group cleaves to give a resonance-stabilized cation and a radical. However, intramolecular dehydration...
Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...


