对于胃癌和食道癌的循环IgG片段
Eugene I Goufman1, Nataliia B Tikhonova1, Andrey P Aleksankin1
1Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|July 13, 2024
概括
血清中免疫球蛋白G (IgG) 氨酸 (IgG-LysK) 片段的升高水平可能有助于早期检测胃和食道癌症. 这种生物标志物有望改善癌症诊断.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 胃和食道癌症对健康构成重大挑战,需要改进早期检测方法.
- 当前的诊断方法可能并不总是能够在早期,最易于治疗的阶段识别这些癌症.
研究的目的:
- 研究免疫球蛋白G (IgG-LysK) 的蛋白质分解片段作为胃癌和食道癌的生物标志物的潜力.
- 评估IgG-LysK在癌症检测中的诊断准确性和临床实用性.
主要方法:
- 分析了来自胃癌 (n=68),食道癌 (n=43) 患者和健康捐赠者的血清样本 (n=20).
- 测量了IgG-LysK的水平,以及血液静止指标 (原血红素时间,纤维素原,等离子原,a2-抗等离子素,蛋白C) 和总IgG.
- 采用接收器操作特征 (ROC) 分析来评估诊断性能.
主要成果:
- 与健康对照人群相比,食道和胃癌患者的IgG-LysK水平中位数显著更高.
- 对于食道癌,ROC分析显示高灵敏度 (91%) 和特异性 (85%),对于胃癌则显示中度灵敏度 (68%),高特异性 (85%).
- 假阴性结果与晚期癌症阶段,转移,较低的总IgG,增加的a2-抗等离子素和较短的前列血时间有关,这表明血液平衡改变了.
结论:
- 在胃癌和食道癌的早期阶段,循环IgG-LysK水平增加.
- IgG-LysK 具有作为这些癌症早期检测生物标记物的潜力,特别是当与其他标记物结合使用时.
- 进一步研究血液静止在假负IgG-LysK结果中的作用是有必要的.
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