萨科佩尼亚对肝细胞癌治疗结果的负面影响
Annalisa Cespiati1,2, Daniel Smith1,2, Rosa Lombardi1,2
1SC Medicina ad Indirizzo Metabolico, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milan, Italy.
Cancers
|July 13, 2024
概括
肌肉质量损失的萨尔科佩尼亚会对肝细胞癌 (HCC) 患者在所有治疗过程中的结果产生负面影响. 早期检测和恢复肌肉质量的干预措施对于改善HCC的生存率和治疗反应至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 肝细胞癌 (HCC) 是一个重要的全球健康问题,具有复杂的病因因素和治疗方式.
- 被定义为骨肌肉质量,强度和功能的损失的萨尔科佩尼亚,越来越被认为是HCC的关键预后因素.
- 本综述重点关注的是肉症对接受肝移植,切除手术,局部治疗和全身治疗的HCC患者的结果的影响.
研究的目的:
- 系统地审查和分析关于类病与肝细胞癌 (HCC) 治疗结果之间的关联的现有文献.
- 阐明瘤症作为各种HCC治疗策略的预后指标的作用.
- 强调需要个性化管理方法,考虑到HCC患者的肉症.
主要方法:
- 使用同行评审的文章进行了全面的文献搜索.
- 搜索的重点是研究在HCC患者的萨尔科佩尼亚和治疗结果的研究.
- 数据从创建开始收集到2023年10月.
主要成果:
- 萨科佩尼亚在HCC患者中很普遍,由于不同的诊断标准,报告的频率有所不同.
- 在所有主要的HCC治疗方式中,肉症独立地与较差的整体存活率 (OS),无复发存活率 (RFS) 和无进展存活率 (PFS) 相相关.
- 麻症与不良事件增加有关,特别是与氨酸激酶抑制剂 (TKIs) 和手术干预,以及诊断时较大的瘤大小. 治疗后肌肉质量下降是减少OS的关键决定因素.
结论:
- 无论是先前存在的还是治疗后发展的肉类,都会对所有治疗策略中的HCC治疗反应和生存产生不利影响.
- 在开始治疗之前评估皮症对于患者的预后和量身定制治疗方法至关重要.
- 需要进行进一步的研究,以探讨肉类症对HCC复发和肝外传播的影响,并研究治疗方法,如监督体育活动,以恢复肌肉质量和改善生存状况.
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