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卵巢边界血清性瘤中的埃索诺菲尔细胞作为BRAF突变的预测因子

Alina Badlaeva¹, Anna Tregubova¹, Andrea Palicelli²

¹National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, 117513 Moscow, Russia.

|July 13, 2024

概括

卵巢血清边缘性瘤 (SBTs) 中的异性细胞 (ECs) 可能表明BRAF V600E突变,这表明进展风险较低. 这一发现可能会导致EC作为SBTs中这种突变的主要查测试.

科学领域:

妇科病理学妇科病理学
分子病理学分子病理学
在瘤学瘤学.

背景情况:

具有BRAF V600E突变的卵巢血清边缘瘤 (SBTs) 显示出进展为低度血清癌的风险降低.
预先的观察表明,菌细胞 (ECs) 与SBTs中的BRAF V600E突变之间存在潜在的联系.

研究的目的:

评估在卵巢SBTs中对乙酸性细胞 (EC) 评估的观察者间可重复性.
确定EC是否可以作为BRAF V600E突变存在的可靠指标.

主要方法:

对42个卵巢SBT样本进行ECs存在的分析.
免疫组织化学染色和基因分析以检测BRAF V600E突变.
使用科恩的卡帕系数对观察者间协议的评估.

主要成果:

在45% (19/42) 的病例中发现了BRAF V600E突变.
在EC评估中观察到实质性的观察者间可重复性 (κ = 0.7).
在预测BRAF V600E突变方面,ECs表现出高灵敏度 (79%) 和特异性 (91%).

结论:

卵巢SBTs中的埃索诺菲尔细胞是一种具有显著预后价值的可重现发现.
在SBTs中,EC可以作为有效的初步查工具,用于识别BRAF V600E突变.
BRAF V600E突变的存在与患者年龄较小和非侵入性植入物的发病率较低有关.

关键词:

在BRAF V600E突变中.这种细胞是eosinophilic细胞.卵巢血清边缘性瘤

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