表观遗传钟与膀癌风险之间的重要关联
Yang Deng1, Chia-Wen Tsai2,3, Wen-Shin Chang2,3
1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200031, China.
Cancers
|July 13, 2024
概括
通过像HannumAge和HorvathAge这样的表观遗传钟来衡量加速的生物衰老,与增加膀癌风险有关. 这项大型研究提供了这种关联的第一个证据,强调了衰老是膀癌症发展的一个因素.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 膀癌不成比例地影响老年人,超过75%的病例发生在65岁及以上的人群中.
- 加快的生物衰老是众所周知的各种癌症的风险因素.
- 表观遗传钟,生物年龄指标和膀癌风险之间的关系尚未得到充分理解.
研究的目的:
- 研究四个已确定的表观遗传时钟 (HannumAge,HorvathAge,GrimAge,PhenoAge) 与膀癌风险之间的关联.
- 为了确定加速生物衰老是否预测了对膀癌的易感性增加.
主要方法:
- 采用了一个大型病例控制研究设计.
- 权重遗传风险得分 (GRS) 是使用与表观遗传钟相关的单核酸多态 (SNP) 构建的.
- 门德尔的随机化 (MR) 方法,包括逆变量加权 (IVW),用于评估因果关系.
主要成果:
- 更高的HannumAge和HorvathAgeGRS与膀癌风险增加显著相关 (分别为OR=1.69和OR=1.09).
- 门德尔随机化分析证实了HannumAge,HorvathAge和膀癌风险之间的关联.
- GrimAge和PhenoAge与膀癌风险没有显著关联.
结论:
- 这项研究提供了第一个证据,将特异性表观遗传钟指示的加速生物衰老与更高的膀癌风险联系起来.
- 这些发现表明,除了时间表年龄之外,生物衰老是膀癌病因学的重要因素.
相关概念视频
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K