神经内分泌新生瘤患者生存的性别差异:两个国家数据库的比较研究
Mohamed Mortagy1,2, Marie Line El Asmar3, Kandiah Chandrakumaran4
1Hampshire Hospitals NHS Foundation Trust, Winchester SO22 5DG, UK.
Cancers
|July 13, 2024
概括
神经内分泌瘤 (NENs) 在英国 (NCRAS) 和美国 (SEER) 数据库中显示出女性生存优势 (FSA). 这种生存益处,特别是在肺和胃NEN中,目前的数据仍然无法解释.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 全球神经内分泌瘤 (NENs) 的发病率正在上升.
- 之前的英国数据 (NCRAS) 表明大多数NEN地点的女性生存优势 (FSA).
- 这项研究旨在利用US SEER数据验证这些发现.
研究的目的:
- 为了比较英国 (NCRAS) 和美国 (SEER) 关于神经内分泌瘤的数据库之间的生存数据.
- 为了验证先前在NEN中观察到的女性生存优势.
- 为了调查FSA在不同解剖部位的程度.
主要方法:
- 对14834名 (NCRAS) 和108399名 (SEER) NEN患者的分析.
- 使用受限平均生存时间 (RMST) 和卡普兰-梅尔估计的60个月生存时间的计算.
- 60个月RMST女性生存优势 (FSA) 的量化.
主要成果:
- 女性生存优势 (FSA) 在NCRAS和SEER数据库之间是一致的.
- 在患有肺部和胃神经内分泌瘤的患者中观察到最高的FSA.
- 统计方法证实了两个注册表中类似的生存模式.
结论:
- 美国SEER数据证实了英国NCRAS数据库关于NEN中的FSA的发现.
- 在神经内分泌瘤中观察到的女性生存优势的根本原因仍未确定.
- 需要进一步的研究来阐明在NEN患者中导致FSA的因素.
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