预先存在的免疫力预测了非小细胞肺癌患者对第一线免疫疗法的反应
Anastasia Xagara1, Maria Goulielmaki2, Sotirios P Fortis2
1Laboratory of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Cancers
|July 13, 2024
概括
在NSCLC患者中,先前存在的瘤抗原特异性T细胞 (PreI+) 预测了更好的免疫治疗反应. 患有PreI+和较少免疫抑制细胞的患者在使用免疫检查点抑制剂时的生存率有所改善.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 以T细胞为媒介的抗瘤反应对于免疫疗法的有效性至关重要.
- 在非小细胞肺癌 (NSCLC) 中确定免疫疗法反应的预测生物标志物至关重要.
研究的目的:
- 调查预先存在的瘤抗原特异性T细胞 (PreI+) 作为NSCLC患者免疫治疗生物标志物的预测价值.
- 分析与免疫疗法反应相关的循环免疫细胞的频率.
主要方法:
- 参与了52名接受前线免疫检查点抑制剂 (ICI) 的未经治疗的III/IV期NSCLC患者.
- 使用PBMCs与瘤相关抗原的体外共同培养,量化了PreI+T细胞.
- 通过多色流细胞计进行了对外围血液免疫细胞的免疫类型鉴定.
主要成果:
- 在44%的患者中检测到PREI+T细胞.
- 与PreI-患者相比,PreI+患者的总生存时间 (OS) 中位数显著更高 (未达到vs.321天,p=0.014).
- 预先I+患者的CD3+CD8+PD-1+细胞和较低调节性T细胞 (Tregs) 耗尽率较高. 患有PreI+和低髓质衍生抑制细胞 (M-MDSCs) 的患者有生存优势.
结论:
- 预先存在的瘤抗原特异性免疫,通过PreI+进行评估,是NSCLC中ICI反应的有希望的预测生物标志物.
- 将PreI+状态与外围免疫细胞概况 (例如Tregs,M-MDSCs) 结合起来,可以确定在ICI治疗中具有有利结果的NSCLC患者.
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