正确的教育环境:生命早期的口腔耐受性
Talia R Cheifetz1,2, Kathryn A Knoop1,3
1Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Immunological reviews
|July 13, 2024
概括
早期生活因素,包括母乳和肠道微生物群,通过在断奶期间的关键窗口中教育调节性T细胞 (Tregs) 来建立口腔耐受性.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 口服耐受性抑制了对无害抗原的免疫反应,由调节性T细胞 (Tregs) 介导.
- 口服耐受性的发展始于生命早期,受到母乳成分的影响,在断奶期间的"耐受性窗口"期间.
研究的目的:
- 审查影响口服耐受性诱导早期生命"耐受性窗口"的因素.
- 探索早期生命中调节性T细胞 (Tregs) 的独特教育.
主要方法:
- 关于抗原转位,杯状细胞相关抗原通道 (GAPs) 和它们的调节的文献综述.
- 分析母亲因素,微生物群和饮食在Treg诱导中的作用.
- 检查母乳免疫球蛋白对微生物多样性和抗原呈现的影响.
主要成果:
- 杯状细胞相关抗原通道 (GAPs) 是抗原转位和Treg诱导的关键,由母因子和微生物群调节.
- 哺乳期期间对于Treg诱导至关重要,有高峰水平的有益的细菌代谢物,如短链脂肪酸.
- 母乳免疫球蛋白 (IgA,IgG) 调节微生物组成和上皮相互作用,影响T细胞的抗原呈现.
结论:
- 包括GAP,微生物群衍生代谢物和母乳免疫球蛋白在内的多种因素组合在断奶期间协调Treg的发育.
- 这种早期的免疫教育建立了长期存在的Tregs,这对于维持成人免疫平衡至关重要.
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