深度大脑刺激给患者带来了多长时间的好处?
Esin Bulut1, P Mitchell Johansen2, Alya Elbualy1
1Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
概括
深度大脑刺激 (DBS) 对帕金森病,基本震和 dystonia 提供长期益处,长达十年. 然而,超过10年的数据是有限的,这突显了对DBS寿命的更多研究的需要.
科学领域:
- 神经外科手术 神经外科手术
- 生物医学工程 生物医学工程
- 运动障碍 运动障碍
背景情况:
- 深度大脑刺激 (DBS) 是患者关于治疗持续时间的常见问题.
- 医生需要关于DBS系统寿命和治疗疗效的指导.
- 进行了范围审查,以评估现有文献并确定知识差距.
研究的目的:
- 评估当前关于深度大脑刺激 (DBS) 治疗寿命的文献.
- 为了确定DBS系统组件和有效性在各种神经系统疾病中维持多长时间.
- 确定10年以后关于DBS结果的可用数据的范围.
主要方法:
- 从1987年1月到2023年6月进行了全面的MEDLINE搜索.
- 包括英语的人类和建模研究,平均随访时间至少3年.
- 两位审查员选了734篇文章,最终审查了122篇关于DBS系统功能和治疗功效的数据.
主要成果:
- 患有帕金森病 (PD),基本震 (ET) 和 dystonia 的患者显示持续的运动益处为7到10年,尽管改善减少.
- 刺激关闭分数表明PD和ET的疾病进展.
- 电池寿命是可变的,取决于疾病和编程;超过十年的文献很少.
结论:
- 关于DBS寿命的现有数据是有限的,特别是对于超过10年的结果.
- 鼓励拥有长期患者数据 (超过10年) 的医生公布他们的发现.
- 需要进一步的研究才能充分了解DBS系统的长期性能和有效性.
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