在乳腺癌中冠状动脉和心肌的纵向评估,使用冠状动脉计算机断层血管学
Chunrong Tu1, Hesong Shen1, Xiaoqin Li1
1Department of Radiology, Chongqing University Cancer Hospital, Chongqing Cancer Institute, and Chongqing Cancer Hospital, Chongqing, China.
JACC. Cardiovascular imaging
|July 13, 2024
概括
冠状动脉CTA揭示了癌症治疗后心脏动脉和肌肉的变化. 基线动脉狭窄和CT-FFR预测乳腺癌患者接受 antracycline 治疗的心脏功能障碍.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 放射学 放射学是一门学科.
- 心血管成像 - 心血管成像
背景情况:
- 与癌症治疗相关的心脏功能障碍 (CTRCD) 的风险很大.
- 对冠状动脉计算机断层扫描血管造影 (CTA) 和左心室 (LV) 心肌变化的有限理解 CTRCD.
研究的目的:
- 使用冠状动脉CTA评估冠状动脉和LV心肌变化.
- 评估左乳腺癌 (BC) 患者接受带有或不带有放射治疗的 antracycline 治疗.
主要方法:
- 对接受环素+/-放射治疗的左侧BC患者进行前性研究.
- 冠状动脉CTA在治疗前和治疗后进行,包括CT-FFR,PCATCT减弱和LVECV.
- 后勤回归用于将基线CTA参数与CTRCD关联.
主要成果:
- 治疗后CT-FFR降低;PCAT CT衰减和LV ECV增加 (P <0.05).治疗后CT-FFR降低;PCAT CT衰减和LV ECV增加 (P <0.05).治疗后CT-FFR降低;PCAT CT衰减和LV ECV增加 (P <0.05).
- 与单独化疗相比,化疗放射治疗导致CT-FFR降低,PCAT CT衰减和LV ECV增加.
- 基线冠状动脉狭窄和CT-FFR与CTRCD的发展有关.
结论:
- 多参数冠状动脉CTA提供冠状动脉和心肌的全面评估.
- 基线冠状动脉狭窄和CT-FFR可以作为成像生物标志物,用于预测该患者组中的CTRCD.
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