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Updated: Jun 21, 2025

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Published on: August 6, 2019

探索对外部顶端根再吸收发生的病因贡献

John M Burnheimer¹, Dylan J Baxter², Kathleen B Deeley²

¹Advanced Education Program in Orthodontics and Dentofacial Orthopedics, Seton Hill University, Greensburg, Pa.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

|July 13, 2024

概括

遗传因素,如特定的单核酸多态性 (SNP),在正牙治疗期间与外部角根再吸收 (EARR) 有关. ACT3N和TSC2基因变异与EARR风险有显著的关联.

科学领域:

遗传学是一个遗传学.
矯正牙科矯正牙科是一種矯正牙科.
牙科研究牙科研究

背景情况:

外部角根再吸收 (EARR) 是常见的,正牙治疗的不良结果.
之前的研究表明,对EARR.有遗传倾向.
单核酸多态 (SNP) 是潜在的促成因素.

研究的目的:

为了调查EARR和各种SNP在正牙患者之间的关联.
识别可能使个体易患EARR的特定遗传标记.

主要方法:

分析了218名具有可用放射图的正牙患者.
使用全景放射图,以0-4级量化EARR.
来自唾液样本的DNA被用于通过PCR和TaqMan化学分析SNP.

主要成果:

在ACT3N中的rs678397 SNP (P=0.003) 和TSC2中的rs1051771 SNP (P=0.03) 与EARR有显著的关联.
没有其他测试过的多态体显示出与EARR.R.有显著联系.
第三类缺陷和更长的治疗时间增加了EARR风险.

结论:

基因多态性,特别是ACT3N和TSC2中的多态性,是EARR的确诊危险因素.
应该从临床上评估个别患者的EARR风险因素.
遗传倾向在EARR的发展中起着重要作用.

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