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在脑小血管疾病的认知障碍患者中改变了静止状态的大脑

Ying Zhang^1,2, Minglu Hu^1,2, Siyu Fan¹

¹Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Brain connectivity

|July 13, 2024

概括

大脑小血管疾病 (CSVD) 与认知障碍有关. 这项研究揭示了感觉运动区域的减少大脑 (BEN),与认知衰退相关,提供了新的诊断生物标志物.

科学领域:

神经成像是一种神经成像.
神经学神经学
生物标志物生物标志物

背景情况:

大脑小血管疾病 (CSVD) 是血管认知障碍的主要原因.
以前的研究集中在线性脑成像特征上,忽视了像脑 (BEN) 这样的非线性测量.
了解BEN在CSVD相关认知障碍中的作用,对于推进诊断和治疗至关重要.

研究的目的:

为了调查认知障碍的CSVD患者的大脑 (BEN) 异常.
将BEN与传统的线性成像方法 (ALFF,ReHo) 进行比较.
探索BEN的诊断潜力及其与线性特征的结合.

主要方法:

招募了34名具有认知障碍的CSVD患者和37名健康对照.
计算灰色物质近似 (ApEn) 和样本 (SampEn) 作为BEN指数.
进行了线性分析 (ALFF,ReHo) 并引入了BEN/ALFF和BEN/ReHo比率.
利用相关性分析和支持矢量机 (SVM) 进行诊断评估.

主要成果:

在CSVD患者的感觉运动区域,ApEn和SampEn显著降低.
较低的BEN指数与较差的记忆和执行功能相关.
与ALFF和ReHo相比,BEN表现出不同的区域模式.
使用BEN和比率的SVM分析实现了74.64%的准确性来诊断具有认知障碍的CSVD.

结论:

感觉运动系统的较低复杂性 (减少BEN) 与CSVD的认知缺陷有关.
在CSVD中,BEN提供了对大脑活动改变的独特见解.
将BEN与线性特征相结合,为诊断CSVD相关认知障碍提供了有希望的新生物标志物.

关键词:

大脑的.大脑小血管疾病是大脑小血管疾病.认知障碍是一种认知障碍.功能性磁共振成像技术功能性磁共振成像技术传感器运动器传感器

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