在先天性叶膜血栓塞的高并发症率和对临床表现的影响
Dvir Gatt1, Eveline Lapidus-Krol2, Priscilla P L Chiu3
1Department of Pediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. dvirgatt@gmail.com.
随着伴随性疾病的先天性叶囊气 (CLE) 呈现更严重,需要更密集的护理和更长的住院时间. 诊断时建议对并发症,特别是心脏异常进行查.
科学领域:
- 儿科肺病学 儿科肺病学
- 遗传性肺部异常 遗传性肺部异常
- 医学并发症 医学并发症
背景情况:
- kongenital lobar emphysema (CLE) 是一种罕见的发育性肺异常.
- 儿科CLE患者的并发症 (CM) 的临床影响尚不清楚.
- 之前的研究报告说,CLE的并发病率较低 (15-20%).
研究的目的:
- 研究伴随性疾病对患有CLE的儿科患者的表现和结果的临床影响.
- 确定CLE并发症的患病率及其与疾病严重程度的关联.
主要方法:
- 在2000年至2022年期间被诊断患有CLE的儿科患者的回顾性队列研究.
- 收集了关于患者人口统计,呼吸系统症状,重症监护室 (ICU) 住院和并发症存在的数据.
- 具有并发症和没有并发症的患者之间的临床表现和结果的比较.
主要成果:
- 39%的CLE患者有记录的并发症,最常见的是心血管异常 (22%).
- 患有并发症的患者的急症监护室入院率显著提高 (75%与33%相比),住院时间更长 (中位数为46天与9天),以及对非侵入性呼吸支持的需求增加 (50%与5%相比).
- 两组之间没有观察到性别,满期出生,诊断年龄或病变位置的显著差异.
结论:
- 儿科CLE的并发症与更严重的临床表现有关.
- 更高的ICU入院率,长时间住院,以及需要呼吸支的需求与伴随性疾病的存在有关.
- 在诊断CLE时,建议对并发症,特别是心脏和尿道异常进行查.
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