在接受完整FESS的CRSwNP患者中复发的模式
Lirit Levi1, Shany Havazelet2, Yonatan Reuven2
1Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel. liritcoh@gmail.com.
概括
慢性鼻炎和鼻多重症 (CRSwNP) 的三分之二的患者经历了手术后的复发. 高血清乙氨基酸标志着复发的风险,特别是聚合体的复发,需要更好的治疗标志物.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
背景情况:
- 慢性鼻炎与鼻多重症 (CRSwNP) 经常在手术后复发.
- 了解复发模式和诱导因素对于有效管理至关重要.
研究的目的:
- 在功能性内镜外科手术 (FESS) 后分析CRSwNP的复发模式.
- 确定与CRSwNP患者不同复发模式相关的诱导因素.
主要方法:
- 对114名接受完整FESS的CRSwNP患者的回顾性分析.
- 复发的分类为,多或正常内镜检查,以及早期 (≤6个月) 和晚期.
- 使用单变量,多变量物流和考克斯回归模型进行统计分析,以确定风险因素.
主要成果:
- 在65.8%的患者中观察到复发,平均时间为12.9个月.
- 聚复发发生在46.7%,胀发生在53.3%. 早期复发 (在6个月内) 发生在41%的患者中.
- 血清清 >500细胞/μL显著与复发 (RR=1.62) 和多复发 (RR=3.9) 相关.
结论:
- 三分之二的CRSwNP患者在两年内经历了术后复发 (胀或多).
- 血清好色素 > 500 细胞/μL 是复发的关键危险因素,特别是聚合体复发.
- 为了改善CRSwNP管理中的治疗分配,需要更准确的标记物.
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