通过植物产品及其纳米配方准胰腺瘤微环境
Mohamed J Saadh1, Mohammed Ahmed Mustafa2, H Malathi3
1Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Medical oncology (Northwood, London, England)
|July 13, 2024
概括
植物化学物质,植物衍生化合物,在向胰腺癌方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 癌症生物学 癌症生物学
背景情况:
- 由于治疗选择有限,胰腺癌存在重大治疗挑战.
- 瘤层,包括多种细胞和细胞外成分,极大地影响瘤的进展和化学抵抗.
- 向瘤侧膜是胰腺癌治疗的有希望的策略.
研究的目的:
- 审查植物化学品对胰腺瘤微环境的影响.
- 探索植物化学品在克服耐化学物质和提高治疗疗效方面的潜力.
- 讨论植物化学品与传统疗法的组合.
主要方法:
- 关于植物化学品和胰腺癌的研究文献综述.
- 针对瘤流体组件 (纤维细胞,ECM,免疫细胞,血管) 的植物化学机制的分析.
- 对植物化学品的免疫调节和抗血管效应的评估.
主要成果:
- 植物化学物质可以调节 stromal 激活中的关键途径,破坏瘤-stroma 通信.
- 植物衍生化合物通过影响瘤微环境,表现出抗癌性质.
- 植物化学物质显示出降低化学阻力和使瘤对治疗敏感的潜力.
结论:
- 植物化学物质提供了一种可行的策略,用于重塑胰腺瘤.
- 用植物化学物质准瘤侧膜可能会改善胰腺癌的治疗结果.
- 将植物化学品与化疗,免疫疗法或放射治疗结合起来需要进一步研究.
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