相关实验视频
Updated: Jun 21, 2025

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
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化疗期间骨肌功能变化和急性白血病患者的相关因素
Yusuke Terao1,2, Yasuhide Nakayama3,4, Masahiro Abo4
1Department of Rehabilitation Medicine, The Jikei University School of Medicine Hospital, Tokyo, Japan. t-yusuke@jikei.ac.jp.
概括
在接受化疗的急性白血病患者中,骨肌肉数量显著下降. 老年和男性性别被确定为影响这种下降的关键因素.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 放射学 放射学是一门学科.
背景情况:
- 骨肌功能是急性白血病 (AL) 的关键预后指标.
- 在AL患者的化疗期间骨肌肉功能障碍仍然不明.
- 这项研究调查了在alo-HSCT之前的化疗期间影响骨肌肉变化的因素.
研究的目的:
- 在AL患者的化疗期间评估骨肌量和质量的变化.
- 为了确定影响这些骨肌肉变化的因素.
- 在 allo-HSCT 之前了解化疗对骨肌肉功能的影响.
主要方法:
- 在alo-HSCT之前接受化疗的90名AL患者的回顾性队列研究.
- 通过CT扫描通过psoas肌肉指数 (PMI) 评估的骨肌量.
- 骨肌质量通过CT扫描通过计算机断层扫描 (CTV) 值进行评估.
主要成果:
- 从化疗前到alo-HSCT前观察到骨肌量 (PMI) 的显著下降 (p < 0.001).
- 在两个时间点 (p = 0.798) 之间,骨肌质量 (CTV) 没有显著差异.
- 逐步的多重回归确定了年龄较大 (p=0.019) 和男性性别 (p=0.001) 作为与PMI降低相关的因素.
结论:
- 化疗导致AL患者骨肌量显著减少.
- 骨肌量下降与老年和男性性别有关.
- 这些发现突出了化疗对肌肉质量的影响,并确定了影响这种影响的患者特征.
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