在患有痛风的患者中,冠状动脉心脏病的患病率和相关因素
E L Markelova1, M S Eliseev2, E V Il'inykh2
1Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russia. evgenia-im@yandex.ru.
痛风患者患冠状动脉心脏病 (CHD) 的患病率很高,近40%的人受到影响. 肥胖,痛风严重程度和脏问题等因素显著增加了这些人的心脏病风险.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 痛风与心血管疾病 (CVD) 风险增加有关,包括发病率和死亡率.
- 了解冠心病 (CHD) 和痛风之间的关联对于患者管理至关重要.
研究的目的:
- 为了确定被诊断为痛风的患者中心血管疾病的患病率.
- 为了确定与这种患者群体中心血管疾病发展相关的因素.
主要方法:
- 一项研究对286名患有痛风的男性患者进行了研究.
- 标准临床检查评估了心血管疾病的传统风险因素 (TRF).
- 计算了调整后的赔率比率 (OR) 和95%信心区间 (95%CI).
主要成果:
- 冠状动脉心脏病 (CHD) 在3.8%的痛风患者中被诊断为冠状动脉心脏病;29.7%的人有心肌梗塞 (MI) 的病史.
- 与心血管疾病风险增加显著相关的因素包括腹部肥胖,心血管疾病家族史,更长的痛风持续时间,早期的痛风发作,骨内托菲,腎病,功能衰竭,血清总胆固醇升高和血清肌氨酸升高.
- 与没有心脏病患者相比,患有心脏病的患者年轻,痛风持续时间较短.
结论:
- 心血管疾病的患病率在患有痛风的患者中很大,其中很大一部分患者有心脏病史.
- 传统的心血管疾病风险因素和痛风严重性的指标,如功能衰竭和长时间的疾病持续时间,都会导致痛风患者患上心血管疾病.
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