在人类大动脉解剖中代谢生物标志物的进展和前景
Gaohang Mu1,2, Xiangyu Cao1,2, Lianbo Shao1,2
1Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, 215123, Jiangsu, China.
概括
代谢学分析显示,关键代谢物如胆,血清素和尿素与大动脉剖析 (AD) 有关. 对于特定的AD生物标志物,需要进一步研究整合基因组学和蛋白质组学.
科学领域:
- 心血管研究研究心血管研究
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
背景情况:
- 大动脉解剖 (AD) 对心血管健康构成重大威胁.
- 尽管进行了广泛的研究,但对AD因果关系或发展的特定生物标志物仍然难以捉摸.
研究的目的:
- 使用代谢学数据识别人类AD的潜在代谢物生物标志物.
- 探索与AD病变发生相关的代谢途径.
主要方法:
- 从2003年到2023年对代谢学数据的系统审查和分析.
- 使用MetaboAnalyst 6.0在线系统进行数据审查.
主要成果:
- 代谢动态与AD有很强的相关性.
- 胆,血清素和尿素被确定为AD中经常涉及的代谢物.
- 在AD患者中观察到氨基酸和脂质代谢途径的破坏.
结论:
- 代谢学数据表明,特定的代谢物和途径与AD有关.
- 整合性奥米克方法 (基因组学,转录组学,蛋白质组学) 对于开发明确的AD生物标志物至关重要.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
134
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
134
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
74
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
74