间歇性禁食改善社会互动,减少皮质和海马体的炎症标志物
Martín García-Juárez1,2, Adamary García-Rodríguez1,2, Gabriela Cruz-Carrillo1,2
1Facultad de Medicina, Departamento de Bioquímica, Universidad Autónoma de Nuevo León, Madero y Dr. Aguirre Pequeño. Col. Mitras Centro, C.P. 64460, Monterrey, Nuevo León, Mexico.
Molecular neurobiology
|July 13, 2024
概括
替代性禁食 (ADF) 改善了在怀孕期间接触西方饮食的小鼠的社交互动,并减少了自闭症谱系障碍 (ASD) 类行为. 禁食调节了大脑中的微质复杂性,这表明ASD的潜在非药物治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养精神病学是一种精神病学.
背景情况:
- 自闭症谱系障碍 (ASD) 与神经炎症和微质激活有关.
- 母亲接触西方饮食 (餐厅饮食,CAF) 会诱导后代出现类似ASD的行为和神经炎症.
- 需要进行非药物干预来解决饮食诱导的自闭症类行为.
研究的目的:
- 研究交替禁食 (ADF) 对暴露在CAF饮食中的后代的神经炎症和ASD类行为的影响.
- 探索ADF对微质表型,大脑压力标志物和社会互动的影响.
主要方法:
- 在怀孕期间,小鼠后代接受了控制或CAF饮食,其中一些接受了ADF.
- 分析了血β-基酸盐 (BHB) 水平,免疫细胞群 (CD45+,CD206+) 和微质复杂性.
- 评估了内质网膜 (ER) 压力标志物和社会互动行为.
主要成果:
- 在对照和CAF后代中,ADF增加了血BHB水平.
- 在皮质 (Cx) 和海马体 (Hpp) 中,ADF调节了微质群体,增加了牙状环的复杂性.
- 在暴露于CAF的后代中,ADF改善了社交互动,并在大脑中减弱了ER压力标志物.
- 生物建模表明,Cx中的微质复杂性与改善的社会互动有关.
结论:
- 替代性禁食 (ADF) 可以改善暴露在母亲的西方饮食中的后代的ASD类行为和神经炎症.
- 禁食会影响微细胞的表型和复杂性,影响雄性小鼠的社交互动.
- 在饮食诱导的神经发育变化的背景下,ADF代表了一种有前途的非药物战略,用于调节大脑健康和行为.
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