富含血小板的血治疗膝关节和关节骨关节炎疼痛:一个范围广泛的评论
Grace Tanguilig1, Jaydeep Dhillon2, Matthew J Kraeutler3,4
1Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Current reviews in musculoskeletal medicine
|July 13, 2024
概括
富血小板血 (PRP) 在膝关节骨关节炎中表现有前途,比其他治疗方法提供了同等或更好的结果. 然而,它对关节骨关节炎的有效性仍然不一致,需要更多的研究.
科学领域:
- 整形外科 整形外科 整形外科
- 再生医学是一种再生医学.
- 生物制剂 生物制剂 生物制剂
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 富血小板血 (PRP) 是一种新兴的生物治疗OA.
- 目前关于PRP对膝关节和关节OA的疗效的证据是混合的.
研究的目的:
- 审查关于PRP治疗膝关节和关节骨关节炎的当前文献.
- 综合关于PRP与其他治疗方法相比有效性的发现.
- 确定目前关于OA管理中PRP的研究中的差距.
主要方法:
- 对最近文献进行系统审查.
- 随机对照试验 (RCT) 的分析,将PRP与氨酸 (HA) 和骨髓吸附缩物 (BMAC) 进行比较.
- 对检查OA等级和PRP中的白细胞度的研究的评估.
主要成果:
- 与HA相比,PRP在膝关节OA中显示出显著的临床改善.
- 对于膝关节OA,PRP和BMAC之间的结果没有显著差异.
- 对关节骨质炎的结果不一致,与HA相比没有显著差异.
- 对于关节骨质炎的PRP的有效性不如膝盖骨质炎那么一致.
- 缺乏关于白细胞丰富与白细胞贫乏PRP的优越性的证据.
- 关于OA等级与PRP疗效之间的关联,结果各不相同.
结论:
- PRP注射似乎有利于膝关节OA治疗,产生类似或更好的结果.
- 对于关节骨关节炎的PRP的临床疗效不太一致,需要进一步研究.
- 需要更多具有更大的队列和更长的随访时间的高质量的RCT.
- 目前无法对部OA,白细胞度和OA特定等级的疗效提出建议.
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