在9/11后的退伍军人和服务人员中,白质超强度和轻度TBI
David F Tate1,2,3, Erin D Bigler1,3, Gerald E York4,5
1TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84103, USA.
Military medicine
|July 13, 2024
概括
年长的退伍军人有轻度创伤性脑损伤 (mTBI) 史显示出更多的白质超强度 (WMHs). 这些WMH与记忆和执行功能的认知衰退相关,突出显示了mTBI的长期影响.
科学领域:
- 神经成像和神经科学的神经成像和神经科学
- 创伤性脑损伤研究研究
- 军事医学 军事医学
背景情况:
- 在创伤性脑损伤 (TBI) 后的MRI上,白质超强度 (WMHs) 具有不清楚的神经行为意义,特别是在轻度TBI (mTBI) 的退伍军人中.
- 对退伍军人和服务人员来说,了解mTBI中的WMH至关重要.
研究的目的:
- 在一大批退伍军人中调查WMH,mTBI史,年龄和认知表现之间的关系.
- 在这个人群中确定WMH的潜在临床相关物.
主要方法:
- 对1011名战斗接触过的退伍军人 (22-69岁) 的神经影像和神经行为评估.
- 在mTBI (n=813) 和无mTBI (n=198) 组之间进行比较.
- 对WMH存在,认知功能和其他生物标志物的分析.
主要成果:
- 在mTBI和对照组中,WMH的患病率相似 (39%对37%).
- 根据年龄诊断的相互作用显示,在老年mTBI退伍军人中,WMH增加.
- 增加的WMH与服务相关的残疾相关,IGF-1水平,以及较差的情节性记忆和执行功能处理速度.
结论:
- 在较大的mTBI样本中,头部损伤史和放射性发现之间存在显著的临床关系.
- 需要进行随访MRI和神经行为评估的纵向研究,以了解mTBI后的长期WMH影响.
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