在根覆盖程序后,在牙裂液中表达伤口愈合标志物:随机临床试验的系统审查
Vikender Singh Yadav1, Kanika Makker1, Nitesh Tewari2
1Division of Periodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Archives of oral biology
|July 13, 2024
概括
在牙衰退 (GR) 手术后,牙裂液 (GCF) 中的伤口愈合标志物显示炎症蛋白和MMP-8的暂时增加. 然而,有限的研究和偏见的高风险阻止了关于愈合过程的坚定结论.
科学领域:
- 牙周病学 牙周病学
- 在口腔外科手术.
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 牙衰退 (GR) 治疗涉及各种手术技术.
- 在GR手术后的伤口愈合过程还不太清楚.
- 调查牙裂液 (GCF) 中的伤口愈合标记可以提供洞察力.
研究的目的:
- 系统地审查和调查在手术治疗GR之前和之后GCF中伤口愈合标记的表达.
- 综合当前关于GR手术部位愈合期间GCF标记物变化的证据.
主要方法:
- 通过数据库和手动搜索识别的随机临床试验 (RCT) 的系统审查.
- 在根覆盖程序后,GCF标记表达变化的数据提取和合成.
- 使用Cochrane RoB 2.0对偏差风险 (RoB) 的评估,使用GRADE对证据的确定性.
主要成果:
- 包括四个RCT,包括100名患者,研究15个生物标志物.
- 手术后,GCF细胞因子和炎症蛋白的水平在2-10天内增加.
- 矩阵金属蛋白酶-8 (MMP-8) 水平最初上升,然后下降;总体证据确定性是非常低的,因为高的ROB.
结论:
- 具有显著方法差异的有限研究阻碍了对GR伤口愈合的可靠结论.
- 需要使用标准化GCF采样协议进行精心设计,充足的研究.
- 需要进行进一步的研究,以确定GR外科治疗中GCF标记物的确证据.
相关概念视频
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.9K
Phases of Wound Repair
5.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.9K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K


