基于NIR触发的含负载的分层双氧化薄膜用于局部热协同化疗
Shun Xing1, Haifeng Zhang2, Zhenhao Hou1
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
Journal of colloid and interface science
|July 13, 2024
概括
这项研究提出了一种用于肝细胞癌 (HCC) 治疗的新型聚烯涂层薄膜. 该膜提供,并使用近红外光进行向的热化学疗法,显示了门静脉瘤血栓 (PVTT) 干预的前景.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 门静脉瘤血栓 (PVTT) 是肝细胞癌 (HCC) 死亡的主要原因.
- 在外科植入物上的细菌殖民可以加速PVTT的形成.
- 目前的纳米治疗药物输送面临着系统性毒性挑战.
研究的目的:
- 开发一种 in situ 功能膜,用于针对 PVTT 的局部热化疗.
- 为了提高癌症治疗的疗效,同时尽量减少毒性.
- 在PVTT.中为手术场景提供有针对性的干预.
主要方法:
- 在合金上现场制造聚烯涂层,含的多层双氧化物薄膜.
- 利用近红外 (NIR) 光进行光热转化和药物释放.
- 在体内和体外实验评估抗瘤和抗菌疗效.
主要成果:
- 功能膜的表面温度达到~51°C,NIR功率低 (0.5w/cm2),加速的释放.
- 聚烯涂层起到了屏障作用,减少了正常组织中的释放.
- 在体外和体外表现出卓越的抗瘤和抗菌活性.
结论:
- 在现场开发的功能膜为PVTT提供了一个有前途的局部干预措施.
- 热化疗方法提供精确的药物输送,减少全身毒性.
- 这种技术非常适合PVTT治疗中的手术应用.
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