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Updated: Jun 21, 2025

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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塞拉斯通过NLRP3/Caspase-1/IL-1β信号通路在慢性心力衰竭中发挥抗失律作用

Wuping Tan1, Siyi Cheng1, Qinfang Qiu1

  • 1Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, PR China; Cardiac Autonomic Nervous System Research Center of Wuhan University, PR China; Taikang Center for Life and Medical Sciences, Wuhan University, PR China; Hubei Key Laboratory of Autonomic Nervous System Modulation, PR China; Institute of Molecular Medicine, Renmin Hospital of Wuhan University, PR China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, PR China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|July 13, 2024
PubMed
概括

塞拉斯托尔通过改善心率变化和抑制炎症,显著降低心肌梗塞后的腹腔失常. 这项研究揭示了 celastrol 的存在.

关键词:
自主神经重塑自主神经重塑塞拉斯特罗尔 (celastrol) 是一种心肌梗塞的心脏病发作室内节律失常症 室内节律失常症室腔电气改造 室腔电气改造

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

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Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
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