共同感染在塑造COVID-19严重性的相互作用:扩大范围超越SARS-CoV-2的范围
Budhadev Baral1, Vaishali Saini1, Meenakshi Kandpal1
1Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore 453552, Madhya Pradesh, India.
Journal of infection and public health
|July 13, 2024
概括
与各种病毒和细菌的同时感染显著加剧了COVID-19的严重程度. 这些病原体会扩大炎症并改变免疫反应,导致严重病例的死亡率更高.
科学领域:
- * 传染病 传染病
- * 免疫学 免疫学
- * 病毒学和细菌学
背景情况:
- * 严重的COVID-19病例表现出高死亡率.
- * 与病毒和细菌病原体的同时感染越来越多地与SARS-CoV-2一起报告.
- * 这些共感染模仿COVID-19症状,使诊断和治疗复杂化.
研究的目的:
- * 审查共感染在加剧COVID-19严重性的作用.
- * 了解共感染病原体影响疾病进展的机制.
- * 突出共感染对炎症途径和患者结局的影响.
主要方法:
- *对报告COVID-19患者共感染的研究的文献综述.
- *观察到的病毒和细菌共同感染家族的分析 (例如,Retroviridae,Enterobacteriaceae).
- * 检查共感染对细胞因子风暴和免疫信号通路的影响.
主要成果:
- * 与病毒 (Retroviridae,Flaviviridae,Orthomyxoviridae,Picoviridae) 和细菌 (Mycobacteriaceae,Mycoplasmataceae,Enterobacteriaceae,Helicobacteraceae) 家庭的同时感染很普遍.
- * 同感染病原体可以增强SARS-CoV-2的复制,并引发增强的炎症反应.
- * 同感染严重决定了COVID-19的严重程度,主要是通过高水平的促炎细胞因子和免疫路径调节.
结论:
- * 同感染是严重的COVID-19和死亡率的重要驱动因素.
- *SARS-CoV-2和其他病原体之间的相互作用放大了炎症,包括细胞因子风暴.
- *了解共感染动态对于有效管理严重的COVID-19病例至关重要.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
2.4K
05:23Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
6.1K
相关概念视频
Viral Recombination
23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K
Factors Affecting the Risk of Infection
11.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.6K
Infection
7.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.8K
Pneumonia II: Pathophysiology
247
The pathophysiology of pneumonia involves the following steps:
247
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
Stages of Infection
56.1K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
56.1K
