怀孕期间的酸盐暴露及其与甲状腺激素的关联:一项前性队列研究
Iman Al-Saleh1, Rola Elkhatib1, Reem Alghamdi1
1Environmental Health Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
概括
孕妇接触到高水平的甲酸盐显示出母亲甲状腺激素的显著变化,包括自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH). 这些变化,特别是在怀孕晚期,可能会影响胎儿的发育.
科学领域:
- 环境健康科学 环境健康科学
- 内分泌学 在内分泌学.
- 生殖毒理学 生殖毒理学
背景情况:
- 甲酸 (PAE) 是内分泌干扰的化学物质,可能对孕产妇和胎儿的健康产生影响.
- 以前对子宫内甲酸盐暴露和母体甲状腺激素的研究已经产生了不一致的结果.
- 甲状腺激素对于正常的胎儿生长和神经发育至关重要.
研究的目的:
- 为了前性地评估整个怀孕三个季度的甲酸盐暴露.
- 调查甲酸代谢物水平与母亲甲状腺激素度 (FT4,TSH,TT3) 之间的关联.
主要方法:
- 2019-2022年672名孕妇的前性队列研究.
- 在三个月内收集了七种甲酸盐代谢物的尿样 (MEP,MnBP,MiBP,MBzP,MEHHP,MEOHP,MECPP) 和FT4,TSH和TT3的血清样本.
- 利用线性混合效应模型分析重复的甲酸盐暴露和甲状腺激素关联,调整混因素.
主要成果:
- 检测到对DEP,DBP和DEHP代谢物的广泛暴露,其水平高于其他国家.
- 在几个甲酸盐代谢物 (例如,MEP,MECPP,MEHHP) 和增加的FT4水平之间观察到显著的积极关联.
- 提升的TSH水平与大多数甲酸盐代谢物有关,并且改变的TSH/FT4比率与更高的甲酸盐暴露有关,特别是在第二和第三季度.
结论:
- 在怀孕期间暴露于甲酸盐是普遍存在的,并且与母亲甲状腺激素水平的显著变化有关.
- 这些荷尔蒙变化,特别是在怀孕晚期,表明酸盐可能会影响胎儿发育的潜在机制.
- 这些发现凸显了在怀孕期间进行多次暴露测量的必要性,以准确评估,并强调了甲酸盐暴露对公共健康的相关性.
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