在长期暴露于双-A结构模拟物时,神经行为表型和肠道微生物组成的性变异
Dhirendra Pratap Singh1, Aasish Kumar1, Jignesh Prajapati2
1ICMR-National Institute of Occupational Health (NIOH), Meghani Nagar, Ahmedabad, Gujarat 380016, India.
Journal of hazardous materials
|July 13, 2024
概括
双S (BPS) 和双F (BPF) 暴露会导致焦虑和类似抑郁的行为,特别是在男性中. 这些内分泌干扰物影响肠道微生物,炎症和大脑健康,突出性别特异性风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 双S (BPS) 和双F (BPF) 是消费品中常见的BPA替代品.
- 这些化学物质被怀疑是内分泌干扰物,具有潜在的神经毒性作用.
研究的目的:
- 为了研究BPS和BPF暴露的性别特异的神经行为影响.
- 探索双暴露,炎症,神经递质水平和肠道微生物群之间的关联.
主要方法:
- 标准化神经行为测试,生物化学和分子检测炎症性细胞因子和神经递质.
- 基因表达分析,组织学检查,肠道透性测定和16S-rRNA元基因组学测序.
主要成果:
- 双暴露诱导了焦虑和类似抑郁的行为,特别是在雄性小鼠中.
- 观察到增加的促炎细胞因子,改变的神经递质水平和神经炎症.
- 增加了肠道透性和肠道微生物多样性的显著变化,特别是在男性中.
结论:
- 双暴露对神经行为和肠道微生物群产生性别特异性影响.
- 这些发现强调需要对对双醇的性别依赖反应有细微了解.
- 需要量身定制的监管措施来减轻潜在的健康风险.
相关概念视频
Development of Human Microbiota
61
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
Gut-Brain Axis
222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222


