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Updated: Jun 21, 2025

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Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
Published on: May 3, 2019
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在核反应堆中使用混合-226和加多-157的-225光核生产目标
Artem V Matyskin1, Susanna B Angermeier2, Saleem S Drera3
1Radiation Science and Engineering Center, College of Engineering, Pennsylvania State University, 100 Breazeale Nuclear Reactor, University Park, PA 16802, United States of America.
Nuclear medicine and biology
|July 13, 2024
概括
这项研究展示了一种在核反应堆中生产动-225 (Ac-225) 的新方法. 无废物分离过程产生纯的Ac-225,这对于有针对性的阿尔法疗法的进步至关重要.
科学领域:
- 核化学 核化学 核化学
- 放射性药物科学 放射性药物科学
背景情况:
- 动-225 (Ac-225) 对于向的阿尔法疗法至关重要.
- 有限的Ac-225可用性阻碍了临床试验和放射性药物开发.
研究的目的:
- 通过核反应堆的热中子流量来研究Ac-225的生产.
- 为Ac-225.5开发一种高效且没有废物的分离方法.
主要方法:
- 在核反应堆中,对含有-226 (Ra-226) 和-157 (Gd-157) 的目标进行辐射.
- 使用来自Gd-157中子捕获的快速马光子诱导的226Ra(γ,n) 225Ra反应.
- 使用分支DGA树脂进行脱,分离Ac-227以及随后的Ac-225提取和化.
主要成果:
- 从0.9毫克的Ra-226.6中产生6(1) kBq的-225 (Ra-225) 的产生.
- 通过使用bDGA树脂,成功将Ac-225从Ra-226和Ra-225分离出来.
结论:
- 开发的方法可以在核反应堆内生产Ac-225.
- 在Ac-225分离过程中没有废物,这便于为治疗应用提供纯的Ac-225.
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