精神分裂症谱系障碍的缓解:阿米苏普里德,阿里皮普拉和奥兰扎的随机试验
Petros Drosos1, Erik Johnsen2, Christoffer Andreas Bartz-Johannessen3
1NORMENT, Division of Psychiatry, Haukeland University Hospital, Bergen 5036, Norway; Department of Clinical Medicine, University of Bergen, Bergen 5007, Norway; TIPS-Network for Clinical Research in Psychosis, Clinic For Adult Mental Health, Stavanger University Hospital, Stavanger 4011, Norway.
Schizophrenia research
|July 13, 2024
概括
抗精神病药物轻率和低基线负面症状预测精神分裂症的缓解. 阿米苏尔普里德显示出缓解的潜力,但针对负面症状的新疗法至关重要.
科学领域:
- 精神病学和临床神经科学
- 药理学 药理学是指药理学的学科.
- 心理健康研究 心理健康研究
背景情况:
- 精神分裂症缓解是治疗结果的一个关键指标.
- 识别与缓解相关的因素对于优化患者护理至关重要.
- 通常使用的是第二代抗精神病药物,但缓解率各不相同.
研究的目的:
- 调查与精神分裂症患者缓解相关的因素,这些患者接受了第二代抗精神病药物治疗.
- 为了比较amisulpride,aripiprazole和 olanzapine之间的缓解率.
- 评估负面症状和药物无知对治疗结果的影响.
主要方法:
- BeSt InTro随机对照试验的子研究,涉及126名精神分裂症患者 (ICD-10 F20-29,不包括F23).
- 患者被随机分配给阿米苏普林,阿里皮普拉或奥兰扎.
- 排放率计算在七个时间点,有或没有六个月的时间标准.
主要成果:
- 一年内缓解率为55% (27/49) 没有时间标准和29% (17/59) 有时间标准.
- 抗精神病药物无知和低基线负症状负载与缓解有很强的相关性.
- 阿米苏尔普里德的使用比阿里皮普拉更有可能导致缓解,但不是奥兰zapine.
结论:
- 精神分裂症的负面症状对当前的抗精神病治疗具有显著的抵抗力.
- 低缓解率突显了需要新的治疗策略,特别是对于负面症状.
- 进一步研究针对负面症状的向治疗方法对于改善精神分裂症管理至关重要.
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