经过碳酸盐介导的伊尔贝沙坦先进氧化:一种合适的化替代品?
Antonio Medici1, Antonietta Siciliano2, Giovanni Libralato2
1Department of Chemical Sciences, University of Naples Federico II, Via Vicinale Cupa Cintia 26, 80126 Naples, Italy.
The Science of the total environment
|July 13, 2024
概括
伊尔贝沙坦的活性碳酸盐处理形式超过11个消毒副产品 (DBPs),许多新. 这些DBP比化DBP更有毒,使得这种方法不适合处理易柏沙坦污染的水.
科学领域:
- 环境化学环境化学
- 水处理技术水处理技术
- 药品在环境中的作用
背景情况:
- 伊尔贝沙坦是一种广泛使用的药物,可能会污染水源.
- 传统的水处理方法可能无法有效地去除伊布沙坦,或可能形成有害的消毒副产品 (DBPs).
- 活性碳酸盐 (SPC) 被探索为一种替代处理方法,需要了解其副产品及其对环境的影响.
研究的目的:
- 通过使用活性炭酸盐 (SPC) 处理来调查伊尔贝萨坦的环境命运.
- 识别和描述在SPC处理过程中形成的新型消毒副产品 (DBPs).
- 为了评估来自伊布沙坦的DBP的毒性,并将其与化DBP进行比较.
主要方法:
- 使用活性炭酸盐研究了伊尔贝沙坦的降解.
- 使用色谱技术分离了消毒副产品 (DBPs).
- 使用核磁共振 (NMR) 和质谱 (MS) 确定了DBP结构.
- 使用模型生物 (Daphnia magna,Aliivibrio fischeri,Raphidocelis subcapitata) 和ECOSAR计划评估了DBP的毒性.
主要成果:
- 与化相比,活性碳酸盐处理导致矿化程度较低 (-43%).
- 形成了至少11个DBP,其中8个首次被确定.
- 由SPC处理产生的DBPs被发现比化产生的DBPs更有毒.
- 关于毒性的ECOSAR预测与实验发现保持一致.
结论:
- 活性碳酸盐处理不适合从污染水中去除伊尔贝沙坦,原因是大量的,高度有毒的DBPs的形成.
- DBP的毒性与它们的化学结构有关,特别是芳香和基组.
- 需要进一步的研究来开发有效和安全的方法来从水中去除伊尔贝萨坦.
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