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表观遗传年龄加速的地图:全球分析

Igor Yusipov¹, Alena Kalyakulina¹, Arseniy Trukhanov²

¹Artificial Intelligence Research Center, Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod 603022, Russia; Institute of Biogerontology, Lobachevsky State University, Nizhny Novgorod 603022, Russia.

Ageing research reviews

|July 13, 2024

概括

表观遗传衰老加速在全球范围内有所不同,男性的衰老速度比女性更快. 杜尼丁PACE测量显示了反映社会经济因素的潜力,与其他表观遗传时钟不同.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
基因组学就是基因组学.
人口健康人口健康

背景情况:

表观遗传加快年龄是生物衰老的生物标志物.
在表观遗传年龄加速的全球变异并未得到充分理解.
现有的表观遗传时钟在跨组织和跨人群适用性方面存在局限性.

研究的目的:

通过使用最大的公开DNA甲基化数据集,系统地分析全球表观遗传衰老加速.
评估不同地理和种族群体中流行表观遗传钟的性能和一致性.
调查地理,种族和健康状况对表观遗传年龄加速的影响.

主要方法:

分析了来自25个国家和31个种族的93个公共DNA甲基化数据集 (23K个健康样本).
利用流行的表观遗传钟 (PhenoAge,GrimAge,DunedinPACE) 来评估年龄加速.
检查了模型质量指标和推断能力到不同的组织和年龄范围.

主要成果:

在不同的表观遗传时钟模型中观察到显著的不一致性.
芬诺时代倾向于低估,而格林时代版本高估了表观遗传年龄.
DUNEDINPACE与社会经济指标相关,但仅限于血液数据.
在大多数人群中,男性表现出比女性更快的表观遗传衰老.

结论:

目前的表观遗传钟在全球应用和一致性方面存在局限性.
由于数据的局限性,地理,种族和健康因素难以分离.
杜内丁PACE在反映人口水平健康差异方面表现有前途.
在表观遗传衰老中的基于性别的差异是一个一致的全球发现.

关键词:

年龄加速的加速度.通过DNA甲基化.基因表观时钟是什么?民族身份民族身份衰老的步伐衰老的速度种族种族种族种族性别特异性性别特异性

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