亚麻补充剂是否会影响阿波脂蛋白? 一个GRADE评估的系统审查和元分析
Sasan Pourbagher Benam1, Seyedsaber Mirabdali2, Negar Ebrahimi3
1Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Prostaglandins & other lipid mediators
|July 13, 2024
概括
在成年人中,亚麻补充剂显著降低了apo-BI和lipo (a) 水平. 虽然对一些apolipoproteins有益,但亚麻没有影响apo-AI水平,这表明潜在的心血管益处.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 生物化学 生物化学
背景情况:
- 关于亚麻对阿波利波蛋白的影响存在相互矛盾的结果.
- 脂蛋白是心血管风险的关键指标.
- 了解亚麻的影响对于饮食建议至关重要.
研究的目的:
- 系统地评估亚麻补充剂对成人阿波利波蛋白的影响.
- 通过元分析解决现有研究中的差异.
- 提供关于亚麻在管理阿波利波蛋白水平中的作用的最终证据.
主要方法:
- 随机临床试验 (RCT) 的系统文献搜索至2024年6月.
- 搜索的数据库:PubMed,Scopus,Embase,和科学网. 搜索的数据库:PubMed,Scopus,Embase,和科学网. 搜索的数据库:PubMed,Scopus,Embase,和科学网.
- 使用随机效应模型和标准化平均差异 (SMD) 与95%置信区间 (CI) 的元分析.
主要成果:
- 亚麻补充剂显著降低了阿波利波蛋白B-I (apo-BI) 的水平 (SMD: -0.57;95% CI: -0.95, -0.19).
- 脂质蛋白 (a) [脂质蛋白 (a) ]水平也显著下降 (SMD: -0.34;95%CI: -0.59, -0.09).
- 在阿波利波蛋白A-I (apo-AI) 水平上没有观察到显著变化 (SMD: -0.37;95% CI: -0.87,0.13).
结论:
- 亚麻补充剂对特定的阿波利波蛋白,即apo-BI和lipo (a) 显示了潜在的有益影响.
- 在这次元分析中,对apo-AI水平的影响在统计学上并不显著.
- 建议进一步进行高质量的长期临床试验,以证实这些发现.
更多相关视频
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
2.0K
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.3K
相关概念视频
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Lipids: Dietary Sources and Requirements
718
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
718
Blood Studies for Cardiovascular System III: Serum Lipid Profile
152
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
152
Cholesterol: Significance and Regulation
533
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
533
