在系统性炎症性疾病中,因特乐金 (IL) -1 / IL-6 抑制剂相关的药物反应与埃索诺菲利亚和全身症状 (DReSS)
Vivian E Saper1, Lu Tian2, Ruud H J Verstegen3
1Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
概括
来自IL-1/IL-6抑制剂的异氨酸性和系统性症状 (DReSS) 的药物反应可能导致斯蒂尔斯病的致命肺病. 停止这些抑制剂改善了DReSS患者的治疗结果和生存率.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 干白素-1 (IL-1) 和IL-6抑制剂用于静止和静止类疾病.
- 一种罕见但严重的并发症是带有埃索诺菲利亚和全身症状 (DReSS) 的药物反应,通常表现为致命的肺病.
- 在全身炎症的背景下识别DReSS可能是具有挑战性的.
研究的目的:
- 在全身炎症疾病中确定IL-1/IL-6抑制剂相关的DReSS的关键特征和时间.
- 为了比较DReSS发作后停止与继续使用IL-1/IL-6抑制剂的结果.
主要方法:
- 一项涉及儿科专家的国际合作研究.
- 在89例DReSS病例和773例药物暴露对照中表现出特征.
- 在52名停止IL-1/IL-6抑制剂的患者和37名没有停止IL-1/IL-6抑制剂的患者之间比较了结果.
主要成果:
- 与对照组相比,DReSS病例显示肺部并发症和巨细胞激活综合征增加.
- 最初的DReSS症状通常出现在开始IL-1/IL-6抑制剂后的2-8周.
- 停止IL-1/IL-6抑制剂导致更少的药物,降低了巨细胞激活综合征,并改善了生存率,在67%的停止者中,肺部并发症得到解决.
结论:
- 在系统性炎症性疾病中,早期识别IL-1/IL-6抑制剂相关的DReSS至关重要.
- 停用IL-1/IL-6抑制剂显著改善了患者的治疗结果和生存率.
- 避免IL-1/IL-6抑制剂是控制斯蒂尔斯病和类似疾病中的DReSS的关键.
相关概念视频
Allergic Drug Reactions
830
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
830
Allergic Reactions
27.3K
Overview
27.3K
Drugs Used in Lower Respiratory Disorders: Overview
397
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
397
Drugs for Treatment of Diarrhea-Predominant IBS
156
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156
Antiasthma Drugs: Leukotriene Modifiers
269
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
269
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
267
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
267


