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高压氧气通过调节大鼠脊髓的CD73/腺素/A1R轴减轻慢性术后疼痛

Lijun Yin¹, Wenwu Liu², Zhe Zhang³

¹Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anesthesiology and Perioperative medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Anesthesiology, Women and Children's Hospital of Ningbo University, Ningbo City, Zhejiang, China.

The journal of pain

|July 13, 2024

概括

高压氧气 (HBO) 疗法通过调节脊髓腺素循环,有效治疗慢性术后疼痛 (CPSP). 这项研究表明,HBO使疼痛信号通路正常化,为CPSP提供了一个有前途的新疗法.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
高压医学高压医学

背景情况:

慢性术后疼痛 (CPSP) 显著影响患者的康复和生活质量.
人们对CPSP的基本机制仍然不了解.
高压氧 (HBO) 已经显示出减轻神经病痛的潜力,但其在CPSP中的作用尚不清楚.

研究的目的:

在CPSP的老鼠模型中研究HBO的止痛作用.
阐明脊髓腺素循环在HBO诱导的止痛中所起的作用.

主要方法:

用一种皮肤/肌肉切割和收缩 (SMIR) 鼠标模型来诱导CPSP.
每天进行HBO治疗,持续5天.
分析了脊髓腺水平,ATP含量和腺受体 (A1R),CD73和ADK的表达. 药理干预 (CD73抑制剂,A1R抗剂,腺) 用于探讨机制.

主要成果:

SMIR手术导致脚部撤回值和脊髓腺素的降低,增加ATP和A1R,CD73和ADK的表达.
通过HBO治疗,可以缓解机械体,减少ATP,通过CD73激活增加腺,并降低A1R,CD73和ADK的表达.
内耳腺模仿了HBO的止痛作用,而阻断腺通路 (CD73或A1R) 则减弱了HBO的疗效.

结论:

脊髓腺在CPSP的发展中起着至关重要的作用.
通过调节脊髓中的腺生产和新陈代谢,HBO治疗减轻了CPSP.
HBO显示出作为一种有效的治疗策略来管理CPSP的潜力.

关键词:

皮肤/肌肉切口和收缩.氨酸 (Adenosine) 是一种氨酸.慢性术后疼痛慢性术后疼痛细胞外的5′-核酸酶.高压氧化氧化的高压氧化.

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