大麦多糖类通过两个相对独立的途径抑制结直肠癌
Cheng Zhang1, Li Li1, Jiali Lin1
1Department of Food Science and Engineering, Jinan University, Guangzhou 510630, China.
International journal of biological macromolecules
|July 13, 2024
概括
大麦多糖 (BP) 在抑制结肠直肠癌方面显示出显著的潜力. BP通过促进保护性代谢物直接作用,并间接通过丰富有益的肠道细菌,为癌症预防提供双重作用的方法.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 微生物组研究的研究.
背景情况:
- 结肠直肠癌是全球领先的健康问题.
- 多糖因抗瘤特性而闻名,但大麦多糖 (BP) 的作用尚未研究.
- 了解BP对结直肠癌的影响至关重要.
研究的目的:
- 为了研究大麦多糖 (BP) 的抗结直肠癌作用.
- 阐明BP对结直肠癌的抑制作用背后的机制.
- 探索BP在直接和肠道微生物群介导途径中的双重作用.
主要方法:
- 在体内给予血压 (300 mg/kg) 来评估结直肠癌的抑制.
- 对代谢物产生和癌症途径调节的分析.
- 肠道微生物群的分析和肠道屏障功能的评估.
主要成果:
- 血压 (300 mg/kg) 显著抑制了结直肠癌的进展.
- 血压促进了保护性代谢物 (例如,5-(4-氧) -5-phenylimidazolidine-2,4-dione) 和抑制癌症途径 (ERK,PI3K,WNT,JAK-STAT,细胞循环).
- 在BP中丰富了有益细菌 (Colidextribacter,Bilophila,UCG-003),改善了肠道屏障,并调节了代谢物 (L-Glutamic acid) 和代谢途径 (Apoptosis,TGF-β).
结论:
- 大麦多糖 (BP) 显示出显著的结直肠癌抑制作用.
- BP通过直接促进保护性代谢物和肠道微生物群的间接调节而起作用.
- 这些发现突出了BP作为一种潜在的治疗剂结直肠癌通过双重作用机制.
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