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促进炎症的蛋白质S100A9被自然分子准,以防止神经退行发作

Manuela Leri¹, Dan Sun², Željko M Svedružic³

¹Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

International journal of biological macromolecules

|July 13, 2024

概括

促炎蛋白S100A9有助于阿尔茨海默氏症和帕金森病中的神经炎症. 橄油中的氧醇显示出防止S100A9聚合和神经炎症的潜力.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

S100A9蛋白积累与神经退行性疾病 (NDs) 中的神经炎症有关,例如阿尔茨海默病 (AD) 和帕金森病 (PD).
在AD中,S100A9与粉样蛋白-β (Aβ) 和在PD中与α-synuclein (α-synuclein) 联合聚合,促进粉样斑块的形成和神经毒性.
S100A9的氨基原和促炎性质表明它在ND病理生理学中的关键作用.

研究的目的:

调查针对S100A9治疗神经退行性疾病的治疗干预的潜力.
探索天然化合物的作用,特别是来自特级初橄油 (EVOO) 的酸 (HT),在调节S100A9.9中的作用.
评估HT在防止S100A9粉样蛋白自我组合和缓解神经炎症方面的潜力.

主要方法:

研究了西醇 (HT) 与S100A9.9的相互作用.
评估了HT对S100A9粉样蛋白自我组装的影响.
评估HT对S100A9表达和神经炎症调节的影响.

主要成果:

氧醇 (HT) 显示出与S100A9.9相互作用和调节的能力.
HT显示出抑制S100A9.9的氨基基原体自我组装的潜力.
HT可能会减轻与S100A9积累相关的神经炎症反应.

结论:

针对S100A9代表了神经退行性疾病的有前途的治疗策略.
生物活性天然分子,如来自EVOO的氧醇 (HT),具有防止S100A9相关神经炎症的潜力.
对像HT这样的自然化合物的进一步研究对于开发针对NDs的新干预措施至关重要.

关键词:

粉样蛋白聚合物的聚合.自然的多醇是天然的多醇.神经炎症是一种神经炎症.在S100A9蛋白质中.

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