血BDNF度降低和MMSE得分在慢性精神分裂症和轻度认知障碍中存在关联
Martin Gredicak1, Matea Nikolac Perkovic2, Gordana Nedic Erjavec2
1General Hospital Zabok and Hospital for the Croatian Veterans, Zabok, Croatia.
概括
血中脑源性神经营养因子 (BDNF) 的降低与精神分裂症和轻度认知障碍 (MCI) 的认知衰退有关. 较低的BDNF水平与所有参与者的认知测试分数较差相关,这表明BDNF.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 脑源性神经营养因子 (BDNF) 的降低与精神分裂症的认知衰退有关.
- 血BDNF与慢性精神分裂症和轻度认知障碍 (MCI) 的认知功能之间的关联需要进一步调查.
研究的目的:
- 检查血BDNF水平和慢性稳定精神分裂症和MCI患者的认知衰退之间的关联.
- 为了比较血BDNF度和跨患者组和健康对照组的认知表现.
主要方法:
- 包括123名精神分裂症患者,123名MCI患者和208名健康对照.
- 使用迷你心理状态检查 (MMSE),时钟绘图测试 (CDT) 和PANSS认知分级的认知评估.
- 通过ELISA测量血BDNF度,并分析BDNF Val66Met多态性.
主要成果:
- 与健康对照组相比,精神分裂症和MCI患者的血BDNF水平较低.
- 精神分裂症患者的MMSE和CDT得分低于MCI患者和对照组.
- 血BDNF减少与所有参与者的MMSE得分较低显著相关.
结论:
- 血BDNF水平与精神分裂症和MCI的认知功能有关.
- 在这些情况下,较低的BDNF可能作为认知障碍的生物标志物.
- 需要进一步的纵向研究来探索改善认知的策略.
更多相关视频
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
656
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
32.3K
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Biological Causes of Schizophrenia
54
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
54
