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针对人类cathepsin K抑制的新型选择性以proline为基础的类药物

Felipe Cardoso Prado Martins1, Fernanda Dos Reis Rocho1, Vinícius Bonatto1

  • 1Medicinal and Biological Chemistry Group, Institute of Chemistry of São Carlos, University of São Paulo, Avenue Trabalhador Sancarlense, 400, 23566-590 São Carlos/SP, Brazil.

Bioorganic & medicinal chemistry letters
|July 13, 2024
PubMed
概括

研究人员开发了新的基于プロ林的抑制剂,可以选择性地向人类甲素K (CatK),这是骨质疏松症的关键酶. 最强大的抑制剂对CatK具有很高的亲和力,而不会影响其他cathepsins.

关键词:
氨酸蛋白酶酶是什么 氨酸蛋白酶是什么人类cathepsin K 在K酸抑制剂 酸抑制剂严格的模拟模拟硬件

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