孕期暴露于空气污染物扰乱了代谢和胎盘-胎儿表型
Amit Ganguly1, Shubhamoy Ghosh1, Bo-Chul Shin1
1Department of Pediatrics & the UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095-1752, USA.
Reproductive toxicology (Elmsford, N.Y.)
|July 13, 2024
概括
孕期暴露于空气污染 (AP) 损害了怀孕,导致母亲的心血管和代谢问题,模仿孕期糖尿病. 这导致胎盘损伤并影响胚胎发育.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染 (AP) 与不良妊娠结果有关,包括妊娠期糖尿病.
- 通过AP影响胎盘发育和胎儿生长的机制尚未完全理解.
研究的目的:
- 调查AP暴露对孕妇怀孕期间心血管和代谢状况的影响.
- 检查AP对胎盘营养载体,基因表达,DNA甲基化和胎儿发育的影响.
- 阐明AP诱导的胎盘损伤的潜在机制及其后果.
主要方法:
- 在怀孕小鼠中,从16-19个妊娠日开始,对AP进行鼻腔内灌注.
- 评估母亲的心血管参数 (心率,分数缩短) 和代谢状态 (耐葡萄糖,胰岛素抵抗).
- 对胎盘营养物质载体,基因表达 (RNA测序),DNA5'-基甲基化,形态学和胎儿生长参数的分析.
主要成果:
- 暴露在AP中诱导了孕产妇的心率下降,心脏功能下降,高血糖症,葡萄糖不耐受性和胰岛素抵抗.
- 胎盘显示炎症透,,亡,血管干扰,以及营养物质运输体 (Glut3,Fatp1,Cd36,Glut10) 的表达变化.
- AP暴露导致胎盘和胎儿体重降低,胎儿大脑皮质厚度降低,胎盘DNA5'-基甲基化增加,以及扰乱基因表达特征.
结论:
- 孕期AP暴露会触发母亲的炎症和代谢功能障碍,模仿孕期糖尿病.
- AP会导致严重的胎盘损伤,包括改变DNA甲基化和基因表达,影响营养物质的运输和胎儿的发育.
- 这些发现凸显了空气污染对怀孕的有害影响,并强调了需要采取保护措施的必要性.
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