在胰腺切除术后的长期幸存者中评估胰腺形态参数,表皮功能和营养状况及其因果关系
Hirofumi Ichida1, Hiroshi Imamura1, Atsushi Takahashi1
1Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Surgery
|July 13, 2024
概括
胰腺切除术往往导致营养不良和胰腺外分泌功能不充分. 手术后营养不良的危险因素包括胰腺癌,胰腺通道扩张和手术前BMI低.
科学领域:
- 胃肠病学和肝病学
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 胰腺切除术带来胰腺外分泌功能不充分和营养不良的风险.
- 这些并发症的发病率和风险因素需要进一步调查.
研究的目的:
- 为了研究胰腺形态,外分泌功能和胰腺切除术后的长期营养状况.
- 为了确定与胰腺切除术后营养不良相关的危险因素.
主要方法:
- 评估了70名胰腺管切除术和远部胰腺切除术后的患者的营养状况 (体重,BMI,骨肌量).
- 测量了胰腺形态 (胰腺组织质地,残留体积,导管直径) 和表皮功能 (便脂肪分泌试验,静脉).
- 研究了手术因素,胰腺功能和营养状况之间的因果关系.
主要成果:
- 27%和21%的患者分别患有中度和严重的营养不良.
- 手术后的营养不良持续了很长一段时间,体重和肌肉质量下降.
- 胰腺外分衰竭影响了51% (亚临床) 和36% (临床) 的患者.
结论:
- 胰腺管道腺癌,扩大胰腺管,胰腺双管切除术,手术前低BMI和外分泌功能不充分等级是术后营养不良的危险因素.
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