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大麻可能导致创伤患者血小板活性增加

Danielle F Tanner¹, Joel G Eastes¹, Emily A Reeson¹

¹Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA.

American journal of surgery

|July 13, 2024

概括

在创伤患者中使用delta-9-tetrahydrocannabinol (THC) 与血小板活性增加有关,特别是较低的阿拉基酸抑制. 这表明这些人可能需要修改化疗预防策略.

科学领域:

创伤和紧急医疗医学
药理学药理学是指药理学的学科.
血液学血液学血液学

背景情况:

在创伤患者中,delta-9-tetrahydrocannabinol (THC) 的使用与静脉血栓塞栓事件 (VTE) 有关.
血小板抑制在VTE预防中起着至关重要的作用.

研究的目的:

为了研究创伤患者的血小板抑制,有或没有使用THC.
为了比较THC阳性和THC阴性创伤患者之间的阿拉基酸 (AA) 和腺二酸盐 (ADP) 抑制水平.

主要方法:

以血小板映射 (TEG-PM) 测定和尿液药物查 (UDS) 进行的血小板显微镜的追溯审查,从2019-2023.
基于THC状态的平均AA和ADP百分比抑制的比较.

主要成果:

793名患者获得了完整的TEG-PM和UDS数据.
与THC阴性患者 (34.3%) 相比,THC阳性患者 (23.9%) 的AA抑制显着较低 (P < 0.001).
在THC阳性和THC阴性患者之间没有观察到ADP抑制的显著差异 (P = 0.536).

结论:

这项研究首次证实了使用THC的创伤患者血小板活性增加的证据.
这些发现表明,THC可能会损害血小板抑制,可能有助于VTE风险.
需要进一步的研究来探索阿司匹林在THC阳性创伤患者的化疗预防中的作用,以减轻静脉瘤风险.

关键词:

德尔塔-9-四大麻醇 (THC) 是一种血小板激活是指血小板激活.血小板映射绘制地图血栓形成显微镜 (TEG) 是一种血栓形成显微镜.静脉血栓塞栓症 (VTE) 是一种

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