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Updated: Jun 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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在多发性骨髓瘤中使用Cereblon E3联酶调节剂Mezigdomide和Iberdomide

Tanvi H Patel1, Frits van Rhee1, Samer Al Hadidi1

  • 1Department of Hematology and Oncology, Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR.

Clinical lymphoma, myeloma & leukemia
|July 13, 2024
PubMed
概括

像梅西格多米德和伊伯多米德这样的新型CELMoD对多发性骨髓瘤 (MM) 患者有希望. 本综述探讨了它们的机制,疗效和安全性,为复发性或耐火性MM提供了潜在的替代方案.

关键词:
这是一种B细胞成熟抗原.在CELMoDs中,使用的是CELMoDs.

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